Can You Use Niacinamide with Retinol? A Comprehensive Guide


In the world of skincare, niacinamide and retinol are two significant ingredients, each recognized for their unique benefits. But can you use them together? This blog will address the safety of niacinamide and retinol combination, look into products that contain both, explain how to utilize and layer these ingredients effectively, and highlight any potential benefits or side effects.

Is it Safe to Use Them Together?

The combination of niacinamide and retinol has sparked debate among skincare fans and professionals. Fortunately, recent research indicates that these two ingredients can be used together without harmful responses. As retinol, a vitamin A derivative, and niacinamide, a type of vitamin B3, are known to be compatible, they make a powerful combination for treating a variety of skin issues.

Products in the Market:

Several skincare products on the market are formulated with both niacinamide and retinol, offering a convenient solution for those seeking the benefits of both ingredients in one product. Some popular options include:

  1. Paula’s Choice Resist Intensive Repair Cream
  2. The Ordinary Granactive Retinoid 2% in Squalane
  3. La Roche-Posay Retinol B3 Serum
  4. Olay Regenerist Retinol 24 Night Serum
  5. CeraVe Resurfacing Retinol Serum

Benefits of Using Niacinamide and Retinol Together:

Redness on Face

  1. Reduced Inflammation: Niacinamide has anti-inflammatory properties that can help alleviate the potential irritation caused by retinol, making the combination gentler on the skin.
  2. Enhanced Collagen Production: Both niacinamide and retinol stimulate collagen synthesis, contributing to improved skin elasticity and reduced signs of aging.
  3. Brightening and Even Skin Tone: Niacinamide aids in reducing hyperpigmentation, complementing the skin tone evening benefits of retinol.
  4. Minimized Pores: Niacinamide helps regulate oil production and, when combined with retinol, can contribute to the appearance of minimized pores.

Side Effects and Considerations:

Even though both of these ingredients are generally well tolerated, some people may have slight irritation, redness, or dryness, especially when using these ingredients for the first time in their skincare regimen. It is critical to begin with lower concentrations and gradually increase usage to allow your skin to adjust.

How to Use and Layer:

  1. Start Slowly: Introduce one product at a time into your routine, preferably starting with niacinamide before retinol.
  2. Apply Niacinamide in the Morning: Incorporate niacinamide in your morning routine to benefit from its antioxidant properties and support the skin barrier.
  3. Apply Retinol in the Evening: Use retinol in your evening routine to avoid potential sensitivity to sunlight, as retinol can make the skin more susceptible to UV damage.
  4. Use Sunscreen Daily: Both of them can increase sensitivity to the sun. Always use a broad-spectrum sunscreen with at least SPF 30 during the day.
  5. Using then Together: After, incorporating them into your skincare routine separately, then start using them together at the same time. Preferably, using at night, apply niacinamide first then layer retinol on top of it.


The combination of niacinamide and retinol can be a powerful duo in achieving healthier, more radiant skin. With careful consideration, gradual introduction, and proper sun protection, you can harness the benefits of both ingredients to address various skin concerns effectively. Always consult with a dermatologist or skincare professional to tailor a routine that suits your skin type and concerns. For more skincare related information, check out our blog.

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